术前SCC与CYFRA21-1在肺鳞癌患者表达上调及临床意义

Up-regulation of SCC and CYFRA21-1 expression in patients with lung squamous cell carcinoma before operation and its clinical significance

摘要:

目的 分析术前SCC、CYFRA21-1与肺鳞癌临床病理特征、预后之间的关系。方法 收集2017年3月~2018年4月在云南省肿瘤医院确诊的肺鳞癌患者100例为观察组，确诊为肺良性肿瘤患者90名为肺良性肿瘤组、以及正常人群90名为健康人群组。通过电化学发光法对SCC、CYFRA21-1两种指标进行检测。检测SCC、CYFRA21-1含量，分析在肺鳞癌中表达的临床意义。结果 SCC、CYFRA21-1在肺鳞癌中比在肺良性肿瘤、健康人群中含量要高，差异有统计学意义（P＜0.001），并且敏感性均高于其他两组；男性患者的SCC、CYFRA21-1含量高于女性患者，差异具有统计学意义（P＜0.05）；SCC、CYFRA21-1含量在年龄≥60岁的含量高于＜60岁患者，差异无统计学意义（P＞0.05）；有吸烟史患者的SCC含量高于无吸烟史患者，差异无统计学意义（P＞0.05）。CYFRA21-1在吸烟史患者中高表达，差异有统计学意义（P＜0.05）；SCC、CYFRA21-1在有淋巴结转移、远处转移、肿瘤直径≥5 cm、病理分期为晚期时高表达，差异具有统计学意义（P＜0.05）；SCC、CYFRA21-1阳性患者OS、PFS比阴性患者短；SCC、CYFRA21-1两者之间呈正相关,相关系数（r）为0.630。结论 SCC、CYFRA21-1在肺鳞癌中表达上调；SCC、CYFRA21-1与性别之间存在某种内在联系；SCC、CYFRA21-1与肺鳞癌的TNM分期呈正相关；SCC、CYFRA21-1阳性患者OS、PFS比阴性患者短；SCC、CYFRA21-1两者之间呈正相关,相关系数（r）为0.630。

关键词:肺鳞癌;临床病理特征;预后;鳞状上皮细胞癌抗原;细胞角蛋白19片段

Abstract:

Objective To analyze the relationship between preoperative SCC,CYFRA21-1 and clinicopathological features and prognosis of lung squamous cell carcinoma. Methods 100 patients with lung squamous cell carcinoma diagnosed in Yunnan cancer hospital from March 2017 to April 2018 were collected as the observation group, 90 patients with benign lung tumors as the benign lung tumors group and 90 normal people as the normal group. SCC and CYFRA21-1 were detected by electrochemiluminescence. The contents of SCC and CYFRA21-1 were detected to analyze the clinical significance of their expression in lung squamous cell carcinoma.Results The contents of SCC and CYFRA21-1 in lung squamous cell carcinoma were higher than those in benign lung tumors and normal population, the difference was statistically significant (P＜0.001), and the sensitivity was higher than the other two groups. The levels of SCC and CYFRA21-1 in male patients were higher than those in female patients, and the difference was statistically significant (P＜0.05).The levels of SCC and CYFRA21-1 in patients aged ≥60 years were higher than those in patients aged ＜60 years, and the difference was not statistically significant (P＞0.05). SCC content in patients with smoking history was higher than that in patients without smoking history, and the difference was not statistically significant (P＞0.05). CYFRA21-1 was highly expressed in patients with smoking history, and the difference was statistically significant (P＜0.05). SCC and CYFRA21-1 were highly expressed when there were lymph node metastasis, distant metastasis, tumor diameter ≥5cm and pathological stage was advanced, and the difference was statistically significant (P＜0.05). The OS and PFS of SCC and CYFRA21-1 positive patients were shorter than those of negative patients. SCC and CYFRA21-1 were positively correlated with a correlation coefficient (r) of 0.63.Conclusion SCC and CYFRA21-1 were up-regulated in ung squamous cell carcinoma. SCC, CYFRA21-1 and gender have some internal relations. SCC and CYFRA21-1 were positively correlated with TNM staging of lung squamous cell carcinoma. The OS and PFS of SCC and CYFRA21-1 positive patients were shorter than those of negative patients. SCC and CYFRA21-1 were positively correlated, and the correlation coefficient (r) was 0.630.

Key words:Lung squamous cell carcinoma; Clinicopathological features; Prognosis; Squamous cell carcinoma antigen; Cytokeratin 19 fragment